We Have a Vaccine UPDATE: POLL ADDED NOW!!

[Beastdog]

AstraZeneca now reporting data and will go for approval by year end. Oddly two full doses 62% effective and a half dose followed by a full dose is 90% effective. Thatâ€s good though because then the supply goes further. This vaccine doesnâ€t need to be frozen.

I heard that, too. That doesn't make a lot of sense to me, and gives me less confidence the trial was effective.

[3rdgensooner]

AstraZeneca now reporting data and will go for approval by year end. Oddly two full doses 62% effective and a half dose followed by a full dose is 90% effective. Thatâ€s good though because then the supply goes further. This vaccine doesnâ€t need to be frozen.

I heard that, too. That doesn't make a lot of sense to me, and gives me less confidence the trial was effective.

I was just reading about a difference in the spike protein the Moderna and Pfizer vaccines make and the one AstraZeneca's vaccine makes that made me wonder if it would be less effective. The protein subunit produced by the mRNA vaccines seems important to immunity.  The trial is large they may need to tease out the most effective regimen and they should get the numbers to do that. The AstraZeneca Phase 2 showed near 100% neutralizing antibodies at day 56 from the first dose(28 days after the second). Also vaccines that are less effective very often reduce disease severity in a large number of people who end up getting the vaccinated for disease anyway. We see that in the flu vaccine for instance. It often isn't very effective at preventing flu cases but vaccinated people mostly get less ill than unvaccinated people who get the flu. But the data is a bit of a let down after the big numbers Moderna and Pfizer put up. Especially since this one is refrigeration only and they have a lot more doses ready to go. 
I'm thinking target the mRNA vaccines at high risk and health care and shoot up the rest of the population at will with the AstraZeneca vaccine. Switch over or boost as necessary once things are under control.

[ChinaBuck]

China is immunizing now? I thought their first up vaccine was the CanSino vaccine. Which, quite frankly, looks like the worst vaccine candidate out there. 
I think Biden should take a shot right off. And maybe the Pfizer and Moderna execs and scientists. Do it publicly. That'll help diffuse some of the confusion caused by the moronic statements from Harris and Cuomo. Hopefully nobody keels over.

The wifey tells me that they are shooting up critical med staff and critical military right now. She thinks it is the Sinovac version. Takes two shots 28 days apart. No word on when general public get it. She doesnâ€t want to get it. One, since the virus has been tamed in China, and two, sheâ€s worried about potential side effects.

[Jacketbuckeye]

A couple of things.
Many are wondering how an undertaking like vaccinating a population is done. Remember we already do this. We give over 160 million flu shots mostly over just a few months annually. Total vaccinations given per year is about 290 million. So we already know how to do this. The big issue is getting them to the right populations effectively. That and Pfizer's crazy super frozen vaccine's logistics. 
AstraZeneca has officially released all their Phase 2 data. This was already out there and I already knew about it but I'll repeat it. Side effects look minor so it's safe and it looks like it'll be effective. T cell responses were occurring about 2 weeks after the first shot and good antibody responses by the time of the second shot at 28 days. One of their researchers said they could be ready for approval by Christmas. I'm of the opinion given the number of cases here, the UK , and Brazil that they're going to have numbers weeks before that. We'll see. I hope so because I think that it would be a big game changer. They have a lot of doses already manufactured and it will be far easier to distribute as it doesn't have to be frozen.  Plus just having three manufacturers supplying just means greater numbers of vaccine. I think the first vaccines in December , Pfizer and Moderna, will be very targeted at people working with high risk people and coronavirus patients and long term care facilities. If we can get AstraZeneca on board after the first of the year we may be able to just go full bore community vaccination very shortly into the new year like February. They're saying they can produce hundreds of millions of doses. The US has contracted for 300 million enough to immunize 150 million people. 
https://www.foxnews.com/health/oxford-re...mas-report
https://www.foxnews.com/health/oxford-as...der-adults

February would be awesome, and it would far exceed my current expectations. My uneducated thinking is that my family (low-risk, nonessential, young, healthy, and not in public school, so really the last that should get it) won't get the vaccine until late spring/early summer.

[Jacketbuckeye]

AstraZeneca now reporting data and will go for approval by year end. Oddly two full doses 62% effective and a half dose followed by a full dose is 90% effective. Thatâ€s good though because then the supply goes further. This vaccine doesnâ€t need to be frozen.

I heard that, too. That doesn't make a lot of sense to me, and gives me less confidence the trial was effective.

I was just reading about a difference in the spike protein the Moderna and Pfizer vaccines make and the one AstraZeneca's vaccine makes that made me wonder if it would be less effective. The protein subunit produced by the mRNA vaccines seems important to immunity.  The trial is large they may need to tease out the most effective regimen and they should get the numbers to do that. The AstraZeneca Phase 2 showed near 100% neutralizing antibodies at day 56 from the first dose(28 days after the second). Also vaccines that are less effective very often reduce disease severity in a large number of people who end up getting the vaccinated for disease anyway. We see that in the flu vaccine for instance. It often isn't very effective at preventing flu cases but vaccinated people mostly get less ill than unvaccinated people who get the flu. But the data is a bit of a let down after the big numbers Moderna and Pfizer put up. Especially since this one is refrigeration only and they have a lot more doses ready to go. 
I'm thinking target the mRNA vaccines at high risk and health care and shoot up the rest of the population at will with the AstraZeneca vaccine. Switch over or boost as necessary once things are under control.

This makes sense to me. Prior to AZ's results I was thinking Pfizer's goes to the most at-risk populations because Pfizer likely has a more well-developed supply chain so may be able to distribute quickly despite the heightened freezing requirements, and Moderna's goes towards broader populations. Having a third available, though less effective, makes this even easier.

[3rdgensooner]

China is immunizing now? I thought their first up vaccine was the CanSino vaccine. Which, quite frankly, looks like the worst vaccine candidate out there. 
I think Biden should take a shot right off. And maybe the Pfizer and Moderna execs and scientists. Do it publicly. That'll help diffuse some of the confusion caused by the moronic statements from Harris and Cuomo. Hopefully nobody keels over.

The wifey tells me that they are shooting up critical med staff and critical military right now. She thinks it is the Sinovac version. Takes two shots 28 days apart. No word on when general public get it. She doesnâ€t want to get it. One, since the virus has been tamed in China, and two, sheâ€s worried about potential side effects.

Tell her I rolled my eyes. 
The Sinovac looks good. The CanSino version blew it on vector selection. They could probably see if it confers long term immunity in kids.

[3rdgensooner]

AstraZeneca now reporting data and will go for approval by year end. Oddly two full doses 62% effective and a half dose followed by a full dose is 90% effective. Thatâ€s good though because then the supply goes further. This vaccine doesnâ€t need to be frozen.

I heard that, too. That doesn't make a lot of sense to me, and gives me less confidence the trial was effective.

I was just reading about a difference in the spike protein the Moderna and Pfizer vaccines make and the one AstraZeneca's vaccine makes that made me wonder if it would be less effective. The protein subunit produced by the mRNA vaccines seems important to immunity.  The trial is large they may need to tease out the most effective regimen and they should get the numbers to do that. The AstraZeneca Phase 2 showed near 100% neutralizing antibodies at day 56 from the first dose(28 days after the second). Also vaccines that are less effective very often reduce disease severity in a large number of people who end up getting the vaccinated for disease anyway. We see that in the flu vaccine for instance. It often isn't very effective at preventing flu cases but vaccinated people mostly get less ill than unvaccinated people who get the flu. But the data is a bit of a let down after the big numbers Moderna and Pfizer put up. Especially since this one is refrigeration only and they have a lot more doses ready to go. 
I'm thinking target the mRNA vaccines at high risk and health care and shoot up the rest of the population at will with the AstraZeneca vaccine. Switch over or boost as necessary once things are under control.

This makes sense to me. Prior to AZ's results I was thinking Pfizer's goes to the most at-risk populations because Pfizer likely has a more well-developed supply chain so may be able to distribute quickly despite the heightened freezing requirements, and Moderna's goes towards broader populations. Having a third available, though less effective, makes this even easier.

They are designating healthcare workers in high risk setting 1a and long term care residents 1b for the initial shots. This should work fine with the pharmacies working with the long term care facilities. Both Pfizer and Moderna shots likely. Together you are looking at 40 million vaccinated a month. Then healthcare and first responders along with high risk general population next. Then general population. If AstraZeneca can really tweak a 90% response then that will be a fantastic add on with three manufacturers going at it. C'mon Johnson and Johnson one shot regimen. 
BTW it looks like Moderna and Pfizer together can produce enough to get 40 million people vaccinated a month. idk about AstraZeneca but they have already stockpiled frozen vaccine in bulk. Hundreds of millions of doses. They have another month at least to continue getting ready.

[3rdgensooner]

Well my thread title was a little off. The United Kingdom has a vaccine, we don't. We have a bureaucracy. They're being "deliberative". Being slow and inefficient government drones is in their DNA. Intelligent competent people would've had this done at least 2 weeks ago without sacrificing any steps or safety. Swamp creature losers. They're signaling possibly more delays. This looks completely political. The swamp flexing it's muscle to show us they're in charge.

[Erhino]

Idiot anti vaxers in Durham NC. 

https://www.wral.com/news/local/image/19...d=19407392


I hate how hard it is to post pics here. I like the good ol days of copy/paste. Pic urls are sometimes not worth the hassle. 

For those not clicking, some dbags posted a sign over I 40 saying “ Vaccine makers are exempt from liability”

I am fine with a coming Darwin clean up. We get vaxed, and let the RONA take out the fat, stupid, and unhealthy saving us costs of their future medical needs. Sure most idiots will survive, but it is a start.

[Jacketbuckeye]

My BIL, an always-Trumper, is an anti-vaxxer in this case and thinks the vaccine is rushed (he's also adamant that masks don't work). He has said he'll never get vaccinated for COVID. It's not isolated to one end of the spectrum.

[Beastdog]

Nobody should be FORCED to take this vaccine. Nobody. Personally, I feel this would be a poor choice to make. But there is zero logical and fair reason why someone should not be prohibited from making that decision. Within adult population, anyway.

[3rdgensooner]

No one has ever been forced to take a vaccine nor will anyone be forced to take this one. However the shunning of lepers is a time honored tradition. Antivaxxetards are free to be antivaxxetards. But they can't come in my clinic, any hospital, school, or public building. They can't get on a plane. That includes for employment. They can go with the other antivaxxetards and form a sort of leper colony of their own.

[Jacketbuckeye]

No one has ever been forced to take a vaccine nor will anyone be forced to take this one. However the shunning of lepers is a time honored tradition. Antivaxxetards are free to be antivaxxetards. But they can't come in my clinic, any hospital, school, or public building. They can't get on a plane. That includes for employment. They can go with the other antivaxxetards and form a sort of leper colony of their own.

QFT

[Alabuckeye]

Is that shunning for any vaccine or just this one?

[3rdgensooner]

Is that shunning for any vaccine or just this one?

Most. When I run into antivaxxetards I do advise them their child will not work in healthcare and in most gummint jobs. That's the two largest employers BTW. They often say I should respect their opinion or decision. I advise them I do not respect their decision or opinion actually but I respect their right  to make a decision no matter how ill advised. I also advise them they will not be my patients and they are not to come to my clinic. People applying for employment who are not vaccinated are round filed unless they intend to get caught up. I would prefer they be excluded from any public place as a public health measure.